1
L antibodies made also rapidly clear to the clinicians that a reliable predictive factor for outcome was, in fact, lacking [3-7]. The introduction of K-RAS mutational status analysis allowed a reliable selection of resistant patients (i.e. those with mutated K-RAS). However not all K-RAS wildtype cases were also responders to anti-EGFR monoclonal antibodies. This observation made the need for furt
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NAlveolar macrophages play a central role in lung defense [3,36,37]. The class A scavenger receptors (SRA) MARCO and SR-AI/II are expressed on alveolar macrophages and function in innate defenses against inhaled pathogens and particles [7,8,10,11,17]. However, large number of murine alveolar macrophages with SRA deficient are rarely available for in vitro studies. To further investigate the role o
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S from MARCO-/- and SR-AI/II-/- mice, they demonstrate marked decreased binding and phagocytosis of these particles compared to primary AMs from wild type mice (Fig. 6A and Fig. 7A and Fig. 7B). The results confirm that MARCO and SR-AI/II receptors on alveolar macrophages play critical roles in uptake of unopsonized environmental particles and bacteria. Moreover, the reduced, but still demonstrabl
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Les 1, 2). The sequences clustered with different clades and circulating recombinant forms distributed throughout the phylogenetic trees (Table 2), consistent with the breadth of HIV-1 diversity previously described in Cameroon. CRF02_AG-like viruses dominated the clade distribution, infecting 50 of the 46 participants for which both genes were sequenced (Figure 2). Participants infected with vir
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Llowing SIV Challenges of Vaccinated Rhesus Monkeys. J Virol 2012. Epub ahead of print. 12. Bredell H, Martin DP, Van Harmelen J, Varsani A, Sheppard HW, Donovan R, Gray CM, HIVNET028 Study Team, Williamson C: HIV type 1 subtype C gag and nef diversity in Southern Africa. AIDS Res Hum Retroviruses 2007, 23:477?81. 13. Artenstein AW, Hegerich PA, Beyrer C, Rungruengthanakit K, Michael NL, Natrapan
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L antibodies made also rapidly clear to the clinicians that a reliable predictive factor for outcome was, in fact, lacking [3-7]. The introduction of K-RAS mutational status analysis allowed a reliable selection of resistant patients (i.e. those with mutated K-RAS). However not all K-RAS wildtype cases were also responders to anti-EGFR monoclonal antibodies. This observation made the need for furt
1
Kh R, Awazi B, Hewlett I: Increased genetic diversity and intersubtype recombinants of HIV-1 in blood donors from urban Cameroon. J Acquir Immune Defic Syndr 2007, 45:361?63. 6. Ndembi N, Abraha A, Pilch H, Ichimura H, Mbanya D, Kaptue L, Salata R, Arts EJ: Molecular characterization of human immunodeficiency virus type 1 (HIV-1) and HIV-2 in Yaounde, Cameroon: evidence of major drug resistance mu
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Lightly the uptake of fluorescent latex beads by ZK1 cells (Fig. 6B). Furthermore, to determine whether the size of dextran sulfate molecules alters the effect on ZK1 cells' uptake of latex beads, we tested different sizes of DS in the binding/phagocytosis assay. The results indicated thatonly dextran sulfate with smaller molecular weight (5-8kDa) inhibited binding, whereas larger 100-500-kDa dext

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