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Pacity of latex beads similar to primary AMs deficient in MARCO and SR-AI/II. All three clones showed significantly decreased uptake of fluorescent latex beads compared to the wild type primary AMs (Fig. 6A). Observed differences in phagocytic capacity between these clones and parental primary AMs from MS-/- mice may reflect the heterogeneity seen in populations of primary alveolar macrophages.ZK1
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Lightly the uptake of fluorescent latex beads by ZK1 cells (Fig. 6B). Furthermore, to determine whether the size of dextran sulfate molecules alters the effect on ZK1 cells' uptake of latex beads, we tested different sizes of DS in the binding/phagocytosis assay. The results indicated thatonly dextran sulfate with smaller molecular weight (5-8kDa) inhibited binding, whereas larger 100-500-kDa dext
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Dian overall survival (Figure 3). CISH analysis was possible in 44 cases.Survival probability ( )0 0 5 10 15 Months 20 25FISH EGFR = 0.2) of colorectal FISH patients showing Overall 3 (pGCN 2.6 (-------) andcancerEGFR GCN
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Pacity of latex beads similar to primary AMs deficient in MARCO and SR-AI/II. All three clones showed significantly decreased uptake of fluorescent latex beads compared to the wild type primary AMs (Fig. 6A). Observed differences in phagocytic capacity between these clones and parental primary AMs from MS-/- mice may reflect the heterogeneity seen in populations of primary alveolar macrophages.ZK1
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L antibodies made also rapidly clear to the clinicians that a reliable predictive factor for outcome was, in fact, lacking [3-7]. The introduction of K-RAS mutational status analysis allowed a reliable selection of resistant patients (i.e. those with mutated K-RAS). However not all K-RAS wildtype cases were also responders to anti-EGFR monoclonal antibodies. This observation made the need for furt
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NAlveolar macrophages play a central role in lung defense [3,36,37]. The class A scavenger receptors (SRA) MARCO and SR-AI/II are expressed on alveolar macrophages and function in innate defenses against inhaled pathogens and particles [7,8,10,11,17]. However, large number of murine alveolar macrophages with SRA deficient are rarely available for in vitro studies. To further investigate the role o
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S from MARCO-/- and SR-AI/II-/- mice, they demonstrate marked decreased binding and phagocytosis of these particles compared to primary AMs from wild type mice (Fig. 6A and Fig. 7A and Fig. 7B). The results confirm that MARCO and SR-AI/II receptors on alveolar macrophages play critical roles in uptake of unopsonized environmental particles and bacteria. Moreover, the reduced, but still demonstrabl
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Les 1, 2). The sequences clustered with different clades and circulating recombinant forms distributed throughout the phylogenetic trees (Table 2), consistent with the breadth of HIV-1 diversity previously described in Cameroon. CRF02_AG-like viruses dominated the clade distribution, infecting 50 of the 46 participants for which both genes were sequenced (Figure 2). Participants infected with vir