EP2, EP4 also has a lengthier C-terminus, which has been implicated in agonist-induced desensitization and internalization (Nishigaki et al., 1996; Bastepe and Ashby, 1999; Desai et al., 2000). Regardless of the small amounts of intracellular cAMP, when activated adhering to injury, the EP4 receptor has proven to possess neuroprotective properties. It's nicely documented that EP4 receptor activati