Ich is distinct from the wellcharacterized chromosomal instability pathway [15]. Patients with colorectal cancer containing a BRAF mutation or those with CIMP-positive tend to be older, smokers, women, right-sided, and have a higher-grade histology [16, 17]. In light of the aforementioned evidence and other findings that patients with BRAF-mutant and/or CIMP-positive colorectal cancer (particularl